Have you ever suffered from inner tension that you thought was just something you had to live with? Latest research has revealed a condition affecting some (stats are unknown yet) of the population and the best thing of all is that it is treatable. With simple nutrition. Amazing. There will be alot of information over the next few years regarding genetic predisposition to clinical conditions – a new branch of medicine called Nutrigenomics is merging and its very exciting. So back to the condition that causes exacerbation of tension, anxiety and depression…
The effect of pyroluria can have a mild, moderate, or severe depending on the severity of the imbalance. Most individuals show symptoms of zinc and/or B6 deficiencies, which include poor stress control, nervousness, anxiety, mood swings, severe inner tension, episodic anger (an explosive temper), poor short-term memory and depression. Most pyrolurics exhibit at least two of these problems. These individuals cannot efficiently create serotonin (a neurotransmitter that reduces anxiety and depression) since vitamin B6 is an important factor in the last step of its synthesis. Many of these persons appear to benefit from SSRI medications such as Prozac, Paxil, Zoloft, Celexa, etc. However, as with all mind-altering drugs, side effects occur and the true cause of the mental difficulties remains uncorrected. In addition these individuals often have frequent infections and are often identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. As you can imagine an SSRI will not correct these metabolic effects. More healthful benefits may be achieved by giving the appropriate supporting nutrients.
Pyroluria is a genetically determined chemical imbalance involving an abnormality in haemoglobin synthesis. Haemoglobin is the protein that holds iron in the red blood cell. Individuals with this disorder produce too much of a byproduct of haemoglobin synthesis called “kryptopyrrole” (KP) or “hemepyrrole.” Kryptopyrrole has no known function in the body and is excreted in urine.
Kryptopyrrole binds to pyridoxine (vitamin B6) and zinc and makes them unavailable for their important roles as co-factors in enzymes and metabolism. These essential nutrients when bound to kryptopyrrole are removed from the bloodstream and excreted into the urine as pyrroles. Arachidonic acid (an omega-6 fatty acid) also becomes deficient.
Pyroluria is detected by chemical analysis of the abnormal pyroles in urine detectable as a purple (on testing paper) metabolite in called “the mauve factor.
What do you think of this emerging field of medicine and health? Do you find it exciting or daunting? Have you been tested for Pyroluria?
Image courtesy of natural health protocol